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Mechanisms of kinetic stabilization by the drugs paclitaxel and vinblastine

Microtubule-targeting agents (MTAs), widely used as biological probes and chemotherapeutic drugs, bind directly to tubulin subunits and “kinetically stabilize” microtubules, suppressing the characteristic self-assembly process of dynamic instability. However, the molecular-level mechanisms of kineti...

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Dettagli Bibliografici
Pubblicato in:Mol Biol Cell
Autori principali: Castle, Brian T., McCubbin, Seth, Prahl, Louis S., Bernens, Jordan N., Sept, David, Odde, David J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5415019/
https://ncbi.nlm.nih.gov/pubmed/28298489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-08-0567
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