Myostatin Augments Muscle-Specific Ring Finger Protein-1 Expression Through an NF-kB Independent Mechanism in SMAD3 Null Muscle

Smad (Sma and Mad-related protein) 2/3 are downstream signaling molecules for TGF-β and myostatin (Mstn). Recently, Mstn was shown to induce reactive oxygen species (ROS) in skeletal muscle via canonical Smad3, nuclear factor-κB, and TNF-α pathway. However, mice lacking Smad3 display skeletal muscle...

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Vydáno v:Mol Endocrinol
Hlavní autoři: Sriram, Sandhya, Subramanian, Subha, Juvvuna, Prasanna Kumar, Ge, Xiaojia, Lokireddy, Sudarsanareddy, McFarlane, Craig Desmond, Wahli, Walter, Kambadur, Ravi, Sharma, Mridula
Médium: Artigo
Jazyk:Inglês
Vydáno: Endocrine Society 2014
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414928/
https://ncbi.nlm.nih.gov/pubmed/24438338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2013-1179
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