From the Cover: The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides

Non-human primates (NHPs) are currently considered to be the non-rodent species of choice for the preclinical safety assessment of single-stranded oligonucleotide (SSO) drugs. We evaluated minipigs as a potential alternative to NHPs to test the safety of this class of compounds. Four different phosp...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Braendli-Baiocco, Annamaria, Festag, Matthias, Dumong Erichsen, Kamille, Persson, Robert, Mihatsch, Michael J., Fisker, Niels, Funk, Juergen, Mohr, Susanne, Constien, Rainer, Ploix, Corinne, Brady, Kevin, Berrera, Marco, Altmann, Bernd, Lenz, Barbara, Albassam, Mudher, Schmitt, Georg, Weiser, Thomas, Schuler, Franz, Singer, Thomas, Tessier, Yann
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Minipig as Model to Evaluate Oligonucleotide Safety
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414856/
https://ncbi.nlm.nih.gov/pubmed/28123102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfx025
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