Serine-727 Phosphorylation Activates Hypothalamic STAT-3 Independently From Tyrosine-705 Phosphorylation

Transcriptional activity of signal transducer and activator of transcription-3 (STAT-3) is a key element in the central regulation of appetite and energy homeostasis. Activation of hypothalamic STAT-3 has been attributed to cytokine-promoted phosphorylation at tyrosine-705 (Tyr-705). In nonhypothala...

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Publicat a:Mol Endocrinol
Autors principals: Breit, Andreas, Besik, Valeria, Solinski, Hans Jürgen, Muehlich, Susanne, Glas, Evi, Yarwood, Stephen J., Gudermann, Thomas
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2015
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Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414754/
https://ncbi.nlm.nih.gov/pubmed/25584415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1300
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