A20 Inhibits β-Cell Apoptosis by Multiple Mechanisms and Predicts Residual β-Cell Function in Type 1 Diabetes

Activation of the transcription factor nuclear factor kappa B (NFkB) contributes to β-cell death in type 1 diabetes (T1D). Genome-wide association studies have identified the gene TNF-induced protein 3 (TNFAIP3), encoding for the zinc finger protein A20, as a susceptibility locus for T1D. A20 restri...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Endocrinol
Prif Awduron: Fukaya, Makiko, Brorsson, Caroline A., Meyerovich, Kira, Catrysse, Leen, Delaroche, Diane, Vanzela, Emerielle C., Ortis, Fernanda, Beyaert, Rudi, Nielsen, Lotte B., Andersen, Marie L., Mortensen, Henrik B., Pociot, Flemming, van Loo, Geert, Størling, Joachim, Cardozo, Alessandra K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Endocrine Society 2016
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414657/
https://ncbi.nlm.nih.gov/pubmed/26652732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2015-1176
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