Broadly neutralizing antibodies with few somatic mutations and hepatitis C virus clearance

Here, we report the isolation of broadly neutralizing mAbs (bNAbs) from persons with broadly neutralizing serum who spontaneously cleared hepatitis C virus (HCV) infection. We found that bNAbs from two donors bound the same epitope and were encoded by the same germline heavy chain variable gene segm...

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發表在:JCI Insight
Main Authors: Bailey, Justin R., Flyak, Andrew I., Cohen, Valerie J., Li, Hui, Wasilewski, Lisa N., Snider, Anna E., Wang, Shuyi, Learn, Gerald H., Kose, Nurgun, Loerinc, Leah, Lampley, Rebecca, Cox, Andrea L., Pfaff, Jennifer M., Doranz, Benjamin J., Shaw, George M., Ray, Stuart C., Crowe, James E.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2017
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414559/
https://ncbi.nlm.nih.gov/pubmed/28469084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92872
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