Broadly neutralizing antibodies with few somatic mutations and hepatitis C virus clearance

Here, we report the isolation of broadly neutralizing mAbs (bNAbs) from persons with broadly neutralizing serum who spontaneously cleared hepatitis C virus (HCV) infection. We found that bNAbs from two donors bound the same epitope and were encoded by the same germline heavy chain variable gene segm...

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Pubblicato in:JCI Insight
Autori principali: Bailey, Justin R., Flyak, Andrew I., Cohen, Valerie J., Li, Hui, Wasilewski, Lisa N., Snider, Anna E., Wang, Shuyi, Learn, Gerald H., Kose, Nurgun, Loerinc, Leah, Lampley, Rebecca, Cox, Andrea L., Pfaff, Jennifer M., Doranz, Benjamin J., Shaw, George M., Ray, Stuart C., Crowe, James E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414559/
https://ncbi.nlm.nih.gov/pubmed/28469084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92872
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