Broadly neutralizing antibodies with few somatic mutations and hepatitis C virus clearance

Here, we report the isolation of broadly neutralizing mAbs (bNAbs) from persons with broadly neutralizing serum who spontaneously cleared hepatitis C virus (HCV) infection. We found that bNAbs from two donors bound the same epitope and were encoded by the same germline heavy chain variable gene segm...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Bailey, Justin R., Flyak, Andrew I., Cohen, Valerie J., Li, Hui, Wasilewski, Lisa N., Snider, Anna E., Wang, Shuyi, Learn, Gerald H., Kose, Nurgun, Loerinc, Leah, Lampley, Rebecca, Cox, Andrea L., Pfaff, Jennifer M., Doranz, Benjamin J., Shaw, George M., Ray, Stuart C., Crowe, James E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414559/
https://ncbi.nlm.nih.gov/pubmed/28469084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92872
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