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A convergent synthesis of 1,3,4-oxadiazoles from acyl hydrazides under semiaqueous conditions
The 1,3,4-oxadiazole is an aromatic heterocycle valued for its low-lipophilicity in drug development. Substituents at the 2- and/or 5-positions can modulate the heterocycle's electronic and hydrogen bond-accepting capability, while exploiting its use as a carbonyl bioisostere. A new approach to...
Gorde:
| Argitaratua izan da: | Chem Sci |
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| Egile Nagusiak: | , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Royal Society of Chemistry
2017
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5414388/ https://ncbi.nlm.nih.gov/pubmed/28507694 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc00195a |
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