APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer's disease

Alzheimer's disease (AD) age of onset (ADAOO) varies greatly between individuals, with unique causal mutations suggesting the role of modifying genetic and environmental interactions. We analyzed ~50 000 common and rare functional genomic variants from 71 individuals of the ‘Paisa' pedigre...

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Detalhes bibliográficos
Publicado no:Mol Psychiatry
Main Authors: Vélez, J I, Lopera, F, Sepulveda-Falla, D, Patel, H R, Johar, A S, Chuah, A, Tobón, C, Rivera, D, Villegas, A, Cai, Y, Peng, K, Arkell, R, Castellanos, F X, Andrews, S J, Silva Lara, M F, Creagh, P K, Easteal, S, de Leon, J, Wong, M L, Licinio, J, Mastronardi, C A, Arcos-Burgos, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414071/
https://ncbi.nlm.nih.gov/pubmed/26619808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mp.2015.177
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