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Gating of TonB-dependent transporters by substrate-specific forced remodelling

Membrane proteins play vital roles in inside-out and outside-in signal transduction by responding to inputs that include mechanical stimuli. Mechanical gating may be mediated by the membrane or by protein(s) but evidence for the latter is scarce. Here we use force spectroscopy, protein engineering a...

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Udgivet i:Nat Commun
Main Authors: Hickman, Samuel J., Cooper, Rachael E. M., Bellucci, Luca, Paci, Emanuele, Brockwell, David J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413942/
https://ncbi.nlm.nih.gov/pubmed/28429713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14804
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