Structural and functional analysis of Oceanobacillus iheyensis macrodomain reveals a network of waters involved in substrate binding and catalysis

Macrodomains are ubiquitous conserved domains that bind or transform ADP-ribose (ADPr) metabolites. In humans, they are involved in transcription, X-chromosome inactivation, neurodegeneration and modulating PARP1 signalling, making them potential targets for therapeutic agents. Unfortunately, some a...

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Sparad:
Bibliografiska uppgifter
I publikationen:Open Biol
Huvudupphovsmän: Zapata-Pérez, Rubén, Gil-Ortiz, Fernando, Martínez-Moñino, Ana Belén, García-Saura, Antonio Ginés, Juanhuix, Jordi, Sánchez-Ferrer, Álvaro
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Royal Society 2017
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413906/
https://ncbi.nlm.nih.gov/pubmed/28446708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.160327
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