Development of an Efficient G‐Quadruplex‐Stabilised Thrombin‐Binding Aptamer Containing a Three‐Carbon Spacer Molecule

The thrombin‐binding aptamer (TBA), which shows anticoagulant properties, is one of the most studied G‐quadruplex‐forming aptamers. In this study, we investigated the impact of different chemical modifications such as a three‐carbon spacer (spacer‐C(3)), unlocked nucleic acid (UNA) and 3′‐amino‐modi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Aaldering, Lukas J., Poongavanam, Vasanthanathan, Langkjær, Niels, Murugan, N. Arul, Jørgensen, Per Trolle, Wengel, Jesper, Veedu, Rakesh N.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Full Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413854/
https://ncbi.nlm.nih.gov/pubmed/28150905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600654
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados