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The NF1 gene in tumor syndromes and melanoma
Activation of the RAS/MAPK pathway is critical in melanoma. Melanoma can be grouped into four molecular subtypes based on their main genetic driver: BRAF-mutant, NRAS-mutant, NF1-mutant, and triple wild-type tumors. The NF1 protein, neurofibromin 1, negatively regulates RAS proteins through GTPase a...
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| Publicado no: | Lab Invest |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5413358/ https://ncbi.nlm.nih.gov/pubmed/28067895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2016.142 |
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