Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2

Enteropathy-associated T cell lymphoma (EATL) is a lethal, and the most common, neoplastic complication of celiac disease. Here, we defined the genetic landscape of EATL through whole-exome sequencing of 69 EATL tumors. SETD2 was the most frequently silenced gene in EATL (32% of cases). The JAK-STAT...

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Bibliografiset tiedot
Julkaisussa:J Exp Med
Päätekijät: Moffitt, Andrea B., Ondrejka, Sarah L., McKinney, Matthew, Rempel, Rachel E., Goodlad, John R., Teh, Chun Huat, Leppa, Sirpa, Mannisto, Susanna, Kovanen, Panu E., Tse, Eric, Au-Yeung, Rex K.H., Kwong, Yok-Lam, Srivastava, Gopesh, Iqbal, Javeed, Yu, Jiayu, Naresh, Kikkeri, Villa, Diego, Gascoyne, Randy D., Said, Jonathan, Czader, Magdalena B., Chadburn, Amy, Richards, Kristy L., Rajagopalan, Deepthi, Davis, Nicholas S., Smith, Eileen C., Palus, Brooke C., Tzeng, Tiffany J., Healy, Jane A., Lugar, Patricia L., Datta, Jyotishka, Love, Cassandra, Levy, Shawn, Dunson, David B., Zhuang, Yuan, Hsi, Eric D., Dave, Sandeep S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Rockefeller University Press 2017
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Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413324/
https://ncbi.nlm.nih.gov/pubmed/28424246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160894
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