Production of IgG antibodies to pneumococcal polysaccharides is associated with expansion of ICOS(+) circulating memory T follicular-helper cells which is impaired by HIV infection

Dysfunction of T follicular-helper (T(FH)) cells is a possible cause of impaired germinal centre (GC) and IgG antibody responses in individuals with human immunodeficiency virus-1 (HIV-1) infection and might contribute to decreased magnitude and isotype diversification of IgG antibodies to pneumococ...

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Veröffentlicht in:PLoS One
Hauptverfasser: Abudulai, Laila N., Fernandez, Sonia, Corscadden, Karli, Burrows, Sally A., Hunter, Michael, Tjiam, M. Christian, Kirkham, Lea-Ann S., Post, Jeffrey J., French, Martyn A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413043/
https://ncbi.nlm.nih.gov/pubmed/28463977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176641
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