Neuropeptide S (NPS) variants modify the signaling and risk effects of NPS Receptor 1 (NPSR1) variants in asthma

Single nucleotide polymorphisms (SNPs) close to the gain-of-function substitution, Asn(107)Ile (rs324981, A>T), in Neuropeptide S Receptor 1 (NPSR1) have been associated with asthma. Furthermore, a functional SNP (rs4751440, G>C) in Neuropeptide S (NPS) encodes a Val(6)Leu substitution on the...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Acevedo, Nathalie, Ezer, Sini, Kebede Merid, Simon, Gaertner, Vincent D., Söderhäll, Cilla, D’Amato, Mauro, Kabesch, Michael, Melén, Erik, Kere, Juha, Pulkkinen, Ville
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413018/
https://ncbi.nlm.nih.gov/pubmed/28463995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176568
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