A covalently bound inhibitor triggers EZH2 degradation through CHIP‐mediated ubiquitination

Enhancer of zeste homolog 2 (EZH2) has been characterized as a critical oncogene and a promising drug target in human malignant tumors. The current EZH2 inhibitors strongly suppress the enhanced enzymatic function of mutant EZH2 in some lymphomas. However, the recent identification of a PRC2‐ and me...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Wang, Xu, Cao, Wei, Zhang, Jianjun, Yan, Ming, Xu, Qin, Wu, Xiangbing, Wan, Lixin, Zhang, Zhiyuan, Zhang, Chenping, Qin, Xing, Xiao, Meng, Ye, Dongxia, Liu, Yuyang, Han, Zeguang, Wang, Shaomeng, Mao, Li, Wei, Wenyi, Chen, Wantao
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412902/
https://ncbi.nlm.nih.gov/pubmed/28320739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201694058
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