RIG‐I antiviral signaling drives interleukin‐23 production and psoriasis‐like skin disease

Retinoic acid inducible‐gene I (RIG‐I) functions as one of the major sensors of RNA viruses. DDX58, which encodes the RIG‐I protein, has been newly identified as a susceptibility gene in psoriasis. Here, we show that the activation of RIG‐I by 5′ppp‐dsRNA, its synthetic ligand, directly causes the p...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Zhu, Huiyuan, Lou, Fangzhou, Yin, Qianqian, Gao, Yuanyuan, Sun, Yang, Bai, Jing, Xu, Zhenyao, Liu, Zhaoyuan, Cai, Wei, Ke, Fang, Zhang, Lingyun, Zhou, Hong, Wang, Hong, Wang, Gang, Chen, Xiang, Zhang, Hongxin, Wang, Zhugang, Ginhoux, Florent, Lu, Chuanjian, Su, Bing, Wang, Honglin
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412807/
https://ncbi.nlm.nih.gov/pubmed/28377495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201607027
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