USP26 regulates TGF‐β signaling by deubiquitinating and stabilizing SMAD7

The amplitude of transforming growth factor‐β (TGF‐β) signal is tightly regulated to ensure appropriate physiological responses. As part of negative feedback loop SMAD7, a direct transcriptional target of downstream TGF‐β signaling acts as a scaffold to recruit the E3 ligase SMURF2 to target the TGF...

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Publicado no:EMBO Rep
Main Authors: Kit Leng Lui, Sarah, Iyengar, Prasanna Vasudevan, Jaynes, Patrick, Isa, Zul Fazreen Bin Adam, Pang, Brendan, Tan, Tuan Zea, Eichhorn, Pieter Johan Adam
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412796/
https://ncbi.nlm.nih.gov/pubmed/28381482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201643270
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