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A comparative evaluation of models to predict human intestinal metabolism from nonclinical data
Extensive gut metabolism is often associated with the risk of low and variable bioavailability. The prediction of the fraction of drug escaping gut wall metabolism as well as transporter‐mediated secretion (F (g)) has been challenged by the lack of appropriate preclinical models. The purpose of this...
Uloženo v:
| Vydáno v: | Biopharm Drug Dispos |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
John Wiley and Sons Inc.
2017
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5412686/ https://ncbi.nlm.nih.gov/pubmed/28152562 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bdd.2068 |
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