Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer

BACKGROUND: Patients with hereditary diffuse gastric cancer (HDGC), a cancer predisposition syndrome associated with germline mutations of the CDH1 (E-cadherin) gene, have few effective treatment options. Despite marked differences in natural history, histopathology, and genetic profile to patients...

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Udgivet i:J Transl Med
Main Authors: Chen, Ina, Mathews-Greiner, Lesley, Li, Dandan, Abisoye-Ogunniyan, Abisola, Ray, Satyajit, Bian, Yansong, Shukla, Vivek, Zhang, Xiaohu, Guha, Raj, Thomas, Craig, Gryder, Berkley, Zacharia, Athina, Beane, Joal D., Ravichandran, Sarangan, Ferrer, Marc, Rudloff, Udo
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5412046/
https://ncbi.nlm.nih.gov/pubmed/28460635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-017-1197-5
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