Asymmetrical barcode adapter-assisted recovery of duplicate reads and error correction strategy to detect rare mutations in circulating tumor DNA

Deep sequencing is required for the highly sensitive detection of rare variants in circulating tumor DNA (ctDNA). However, there remains a challenge for improved sensitivity and specificity. Maximum-depth sequencing is crucial to detect minority mutations that contribute to cancer progression. The a...

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Udgivet i:Sci Rep
Main Authors: Ahn, Jinwoo, Hwang, Byungjin, Young Kim, Ha, Jang, Hoon, Kim, Hwang-Phill, Han, Sae-Won, Kim, Tae-You, Hyun Lee, Ji, Bang, Duhee
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5411960/
https://ncbi.nlm.nih.gov/pubmed/28462938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep46678
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