Identification of a novel RASD1 somatic mutation in a USP8-mutated corticotroph adenoma

Cushing's disease (CD) is caused by pituitary corticotroph adenomas that secrete excess adrenocorticotropic hormone (ACTH). In these tumors, somatic mutations in the gene USP8 have been identified as recurrent and pathogenic and are the sole known molecular driver for CD. Although other somatic...

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Detalhes bibliográficos
Publicado no:Cold Spring Harb Mol Case Stud
Main Authors: Uzilov, Andrew V., Cheesman, Khadeen C., Fink, Marc Y., Newman, Leah C., Pandya, Chetanya, Lalazar, Yelena, Hefti, Marco, Fowkes, Mary, Deikus, Gintaras, Lau, Chun Yee, Moe, Aye S., Kinoshita, Yayoi, Kasai, Yumi, Zweig, Micol, Gupta, Arpeta, Starcevic, Daniela, Mahajan, Milind, Schadt, Eric E., Post, Kalmon D., Donovan, Michael J., Sebra, Robert, Chen, Rong, Geer, Eliza B.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2017
Assuntos:
Research Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5411693/
https://ncbi.nlm.nih.gov/pubmed/28487882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/mcs.a001602
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