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Predicting Drug-Induced Cholestasis with the Help of Hepatic Transporters—An in Silico Modeling Approach
[Image: see text] Cholestasis represents one out of three types of drug induced liver injury (DILI), which comprises a major challenge in drug development. In this study we applied a two-class classification scheme based on k-nearest neighbors in order to predict cholestasis, using a set of 93 two-d...
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| Publicado no: | J Chem Inf Model |
|---|---|
| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2017
|
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5411109/ https://ncbi.nlm.nih.gov/pubmed/28166633 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.6b00518 |
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