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Pharmacokinetics and Analgesic Effects of Methadone in Children and Adults with Sickle Cell Disease

BACKGROUND: Vaso-occlusive episodes (VOE) are a significant source of morbidity among children and adults with sickle cell disease (SCD). There is little information on methadone use for SCD pain. This investigation evaluated methadone pharmacokinetics in children and adults with SCD, with a seconda...

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Detalhes bibliográficos
Publicado no:Pediatr Blood Cancer
Main Authors: Horst, Jennifer, Frei-Jones, Melissa, Deych, Elena, Shannon, William, Kharasch, Evan D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5411015/
https://ncbi.nlm.nih.gov/pubmed/27572136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.26207
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