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TLR ligands, but not modulators of histone modifiers, can induce the complex immune response pattern of endotoxin tolerance in mammary epithelial cells

Excessive stimulation of the TLR4 axis through LPS reduces the expression of some cytokine genes in immune cells, while stimulating the expression of immune defense genes during a subsequent bacterial infection. This endotoxin tolerance (ET) is mediated via epigenetic mechanisms. Priming the udder o...

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Detalhes bibliográficos
Publicado no:Innate Immun
Main Authors: Günther, Juliane, Petzl, Wolfram, Zerbe, Holm, Schuberth, Hans-Joachim, Seyfert, Hans-Martin
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410871/
https://ncbi.nlm.nih.gov/pubmed/27913794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1753425916681076
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