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Determining the factors driving selective effects of new nonsynonymous mutations

The distribution of fitness effects (DFE) of new mutations plays a fundamental role in evolutionary genetics. However, the extent to which the DFE differs across species has yet to be systematically investigated. Furthermore, the biological mechanisms determining the DFE in natural populations remai...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Huber, Christian D., Kim, Bernard Y., Marsden, Clare D., Lohmueller, Kirk E.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410820/
https://ncbi.nlm.nih.gov/pubmed/28400513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619508114
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