Vasorelaxing Action of the Kynurenine Metabolite, Xanthurenic Acid: The Missing Link in Endotoxin-Induced Hypotension?

The kynurenine pathway of tryptophan metabolism is activated by pro-inflammatory cytokines. L-kynurenine, an upstream metabolite of the pathway, acts as a putative endothelium-derived relaxing factor, and has been hypothesized to play a causative role in the pathophysiology of inflammation-induced h...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Fazio, Francesco, Carrizzo, Albino, Lionetto, Luana, Damato, Antonio, Capocci, Luca, Ambrosio, Mariateresa, Battaglia, Giuseppe, Bruno, Valeria, Madonna, Michele, Simmaco, Maurizio, Nicoletti, Ferdinando, Vecchione, Carmine
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410560/
https://ncbi.nlm.nih.gov/pubmed/28507519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00214
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