Hypermethylation of the CHRDL1 promoter induces proliferation and metastasis by activating Akt and Erk in gastric cancer

CHRDL1 (Chordin-like 1) is a secreted protein that acts as an antagonist of bone morphogenetic protein (BMP). BMP plays a role as an activator of BMP receptor II (BMPR II), which mediates extracellular to intracellular signal transmission and is involved in carcinogenesis and metastasis. Herein, we...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Pei, Yao-fei, Zhang, Ya-jing, Lei, Yao, Wu, Ding-wei, Ma, Tong-hui, Liu, Xi-qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
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Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410293/
https://ncbi.nlm.nih.gov/pubmed/28423564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.15513
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