Direct expression of active human tissue inhibitors of metalloproteinases by periplasmic secretion in Escherichia coli

BACKGROUND: As regulators of multifunctional metalloproteinases including MMP, ADAM and ADAMTS families, tissue inhibitors of metalloproteinases (TIMPs) play a pivotal role in extracellular matrix remodeling, which is involved in a wide variety of physiological processes. Since abnormal metalloprote...

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Bibliographic Details
Published in:Microb Cell Fact
Main Authors: Lee, Ki Baek, Nam, Dong Hyun, Nuhn, Jacob A. M., Wang, Juan, Schneider, Ian C., Ge, Xin
Format: Artigo
Language:Inglês
Published: BioMed Central 2017
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5410052/
https://ncbi.nlm.nih.gov/pubmed/28454584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-017-0686-9
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