Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo

RATIONALE: Direct reprogramming of cardiac fibroblasts to cardiomyocytes has recently emerged as a novel and promising approach to regenerate the injured myocardium. We have previously demonstrated the feasibility of this approach in vitro and in vivo using a combination of four microRNAs (miR-1, mi...

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Bibliographic Details
Published in:Circ Res
Main Authors: Dal-Pra, Sophie, Hodgkinson, Conrad P., Mirotsou, Maria, Kirste, Imke, Dzau, Victor J.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409871/
https://ncbi.nlm.nih.gov/pubmed/28209718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.116.308741
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