Mutant α2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome

Duane retraction syndrome (DRS) is the most common form of congenital paralytic strabismus in humans and can result from α2-chimaerin (CHN1) missense mutations. We report a knockin α2-chimaerin mouse (Chn1(KI/KI)) that models DRS. Whole embryo imaging of Chn1(KI/KI) mice revealed stalled abducens ne...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Nugent, Alicia A., Park, Jong G., Wei, Yan, Tenney, Alan P., Gilette, Nicole M., DeLisle, Michelle M., Chan, Wai-Man, Cheng, Long, Engle, Elizabeth C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409791/
https://ncbi.nlm.nih.gov/pubmed/28346224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI88502
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