Slowed decay of mRNAs enhances platelet specific translation

Platelets are anucleate cytoplasmic fragments that lack genomic DNA, but continue to synthesize protein using a pool of messenger RNAs (mRNAs), ribosomes, and regulatory small RNAs inherited from the precursor megakaryocyte (MK). The regulatory processes that shape the platelet transcriptome and the...

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Bibliographic Details
Published in:Blood
Main Authors: Mills, Eric W., Green, Rachel, Ingolia, Nicholas T.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2017
Subjects:
Platelets and Thrombopoiesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409447/
https://ncbi.nlm.nih.gov/pubmed/28213379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-08-736108
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