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Effect of genetic background on the phenotype of the Smn(2B/-) mouse model of spinal muscular atrophy
Spinal muscular atrophy (SMA) is caused by mutations or deletions in the Survival Motor Neuron 1 (SMN1) gene in humans. Modifiers of the SMA symptoms have been identified and genetic background has a substantial effect in the phenotype and survival of the severe mouse model of SMA. Previously, we ge...
Gardado en:
| Publicado en: | Hum Mol Genet |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5409218/ https://ncbi.nlm.nih.gov/pubmed/28172892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw278 |
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