Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson’s disease

While induced pluripotent stem cell (iPSC) technologies enable the study of inaccessible patient cell types, cellular heterogeneity can confound the comparison of gene expression profiles between iPSC-derived cell lines. Here, we purified iPSC-derived human dopaminergic neurons (DaNs) using the intr...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Sandor, Cynthia, Robertson, Paul, Lang, Charmaine, Heger, Andreas, Booth, Heather, Vowles, Jane, Witty, Lorna, Bowden, Rory, Hu, Michele, Cowley, Sally A., Wade-Martins, Richard, Webber, Caleb
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409122/
https://ncbi.nlm.nih.gov/pubmed/28096185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddw412
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