Imputation of orofacial clefting data identifies novel risk loci and sheds light on the genetic background of cleft lip ± cleft palate and cleft palate only

Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is among the most common human birth defects with multifactorial etiology. Here, we present results from a genome-wide imputation study of nsCL/P in which, after adding replication cohort data, four novel risk loci for nsCL/P are identifie...

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Vydáno v:Hum Mol Genet
Hlavní autoři: Ludwig, Kerstin U., Böhmer, Anne C., Bowes, John, Nikolić, Miloš, Ishorst, Nina, Wyatt, Niki, Hammond, Nigel L., Gölz, Lina, Thieme, Frederic, Barth, Sandra, Schuenke, Hannah, Klamt, Johanna, Spielmann, Malte, Aldhorae, Khalid, Rojas-Martinez, Augusto, Nöthen, Markus M., Rada-Iglesias, Alvaro, Dixon, Michael J., Knapp, Michael, Mangold, Elisabeth
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Association Studies Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5409059/
https://ncbi.nlm.nih.gov/pubmed/28087736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx012
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