Tipifarnib prevents development of hypoxia-induced pulmonary hypertension

AIMS: RhoB plays a key role in the pathogenesis of hypoxia-induced pulmonary hypertension. Farnesylated RhoB promotes growth responses in cancer cells and we investigated whether inhibition of protein farnesylation will have a protective effect. METHODS AND RESULTS: The analysis of lung tissues from...

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Detalhes bibliográficos
Publicado no:Cardiovasc Res
Main Authors: Duluc, Lucie, Ahmetaj-Shala, Blerina, Mitchell, Jane, Abdul-Salam, Vahitha B., Mahomed, Abdul S., Aldabbous, Lulwah, Oliver, Eduardo, Iannone, Lucio, Dubois, Olivier D., Storck, Elisabeth M., Tate, Edward W., Zhao, Lan, Wilkins, Martin R., Wojciak-Stothard, Beata
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408956/
https://ncbi.nlm.nih.gov/pubmed/28395021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvw258
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