Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome

Eukaryotic translation initiation factor eIF5A promotes protein synthesis by resolving polyproline-induced ribosomal stalling. Here, we report a 3.25-Å resolution crystal structure of eIF5A bound to the yeast 80S ribosome. The structure reveals a previously unseen conformation of an eIF5A–ribosome c...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Mol Biol
Prif Awduron: Melnikov, Sergey, Mailliot, Justine, Shin, Byung-Sik, Rigger, Lukas, Yusupova, Gulnara, Micura, Ronald, Dever, Thomas E., Yusupov, Marat
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408928/
https://ncbi.nlm.nih.gov/pubmed/27196944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.05.011
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