Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension

In this protocol, PAH is induced by combining a 60 mg/kg monocrotalin (MCT) injection with increased pulmonary blood flow through an aorto-caval shunt (MCT+Flow). The shunt is created by inserting an 18-G needle from the abdominal aorta into the adjacent caval vein. Increased pulmonary flow has been...

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Detalhes bibliográficos
Publicado no:J Vis Exp
Main Authors: van der Feen, Diederik E., Weij, Michel, Smit-van Oosten, Annemieke, Jorna, Lysanne M., Hagdorn, Quint A.J., Bartelds, Beatrijs, Berger, Rolf M.F.
Formato: Artigo
Idioma:Inglês
Publicado em: MyJove Corporation 2017
Assuntos:
Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408705/
https://ncbi.nlm.nih.gov/pubmed/28287603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/55065
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