Replication and Oncolytic Activity of an Avian Orthoreovirus in Human Hepatocellular Carcinoma Cells

Oncolytic viruses are cancer therapeutics with promising outcomes in pre-clinical and clinical settings. Animal viruses have the possibility to avoid pre-existing immunity in humans, while being safe and immunostimulatory. We isolated an avian orthoreovirus (ARV-PB1), and tested it against a panel o...

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Veröffentlicht in:Viruses
Hauptverfasser: Kozak, Robert A., Hattin, Larissa, Biondi, Mia J., Corredor, Juan C., Walsh, Scott, Xue-Zhong, Max, Manuel, Justin, McGilvray, Ian D., Morgenstern, Jason, Lusty, Evan, Cherepanov, Vera, McBey, Betty-Anne, Leishman, David, Feld, Jordan J., Bridle, Byram, Nagy, Éva
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408696/
https://ncbi.nlm.nih.gov/pubmed/28441762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v9040090
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