Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases

SM is a fundamental component of mammalian cell membranes that contributes to mechanical stability, signaling, and sorting. Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, a reaction catalyzed by SM synthase (SMS)1 in the Golgi and SMS2 at the plasma me...

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Bibliographic Details
Published in:J Lipid Res
Main Authors: Kol, Matthijs, Panatala, Radhakrishnan, Nordmann, Mirjana, Swart, Leoni, van Suijlekom, Leonie, Cabukusta, Birol, Hilderink, Angelika, Grabietz, Tanja, Mina, John G. M., Somerharju, Pentti, Korneev, Sergei, Tafesse, Fikadu G., Holthuis, Joost C. M.
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2017
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5408615/
https://ncbi.nlm.nih.gov/pubmed/28336574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M076133
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