Combined lipidomic and proteomic analysis of isolated human islets exposed to palmitate reveals time-dependent changes in insulin secretion and lipid metabolism

Studies on the pathophysiology of type 2 diabetes mellitus (T2DM) have linked the accumulation of lipid metabolites to the development of beta-cell dysfunction and impaired insulin secretion. In most in vitro models of T2DM, rodent islets or beta-cell lines are used and typically focus is on specifi...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Roomp, Kirsten, Kristinsson, Hjalti, Schvartz, Domitille, Ubhayasekera, Kumari, Sargsyan, Ernest, Manukyan, Levon, Chowdhury, Azazul, Manell, Hannes, Satagopam, Venkata, Groebe, Karlfried, Schneider, Reinhard, Bergquist, Jonas, Sanchez, Jean-Charles, Bergsten, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407795/
https://ncbi.nlm.nih.gov/pubmed/28448538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0176391
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados