Blockade of CaMKII depresses conduction preferentially in the right ventricular outflow tract and promotes ischemic ventricular fibrillation in the rabbit heart

Calcium/calmodulin-dependent protein kinase II (CaMKII) regulates the principle ion channels mediating cardiac excitability and conduction, but how this regulation translates to the normal and ischemic heart remains unknown. Diverging results on CaMKII regulation of Na(+) channels further prevent pr...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Warren, Mark, Sciuto, Katie J., Taylor, Tyson G., Garg, Vivek, Torres, Natalia S., Shibayama, Junko, Spitzer, Kenneth W., Zaitsev, Alexey V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5407168/
https://ncbi.nlm.nih.gov/pubmed/28130334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00347.2016
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