De novo assembly of highly polymorphic metagenomic data using in situ generated reference sequences and a novel BLAST-based assembly pipeline

BACKGROUND: The accuracy of metagenomic assembly is usually compromised by high levels of polymorphism due to divergent reads from the same genomic region recognized as different loci when sequenced and assembled together. A viral quasispecies is a group of abundant and diversified genetically relat...

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Detalhes bibliográficos
Publicado no:BMC Bioinformatics
Main Authors: Lin, You-Yu, Hsieh, Chia-Hung, Chen, Jiun-Hong, Lu, Xuemei, Kao, Jia-Horng, Chen, Pei-Jer, Chen, Ding-Shinn, Wang, Hurng-Yi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406902/
https://ncbi.nlm.nih.gov/pubmed/28446139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12859-017-1630-z
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