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Timp1 Promotes Cell Survival by Activating the PDK1 Signaling Pathway in Melanoma
High TIMP1 expression is associated with poor prognosis in melanoma, where it can bind to CD63 and β1 integrin, inducing PI3-kinase pathway and cell survival. Phosphatidylinositol (3,4,5)-trisphosphate (PIP3), generated under phosphatidylinositol-3-kinase (PI3K) activation, enables the recruitment a...
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| 發表在: | Cancers (Basel) |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
MDPI
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5406712/ https://ncbi.nlm.nih.gov/pubmed/28430130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers9040037 |
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