Lysophosphatidic Acid Is Associated with Atherosclerotic Plaque Instability by Regulating NF-κB Dependent Matrix Metalloproteinase-9 Expression via LPA(2) in Macrophages

Lysophosphatidic acid (LPA), one of the simplest phospholipid signaling molecules, participates in formation and disruption of atherosclerotic plaque. Matrix metalloproteinases (MMPs) contribute to atherosclerotic plaque rupture by involving in extracellular matrix (ECM) degradation and then thinnin...

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Publicado en:Front Physiol
Autores principales: Gu, Chun, Wang, Fang, Zhao, Zhenwen, Wang, Hongyue, Cong, Xiangfeng, Chen, Xi
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2017
Materias:
Physiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406459/
https://ncbi.nlm.nih.gov/pubmed/28496416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00266
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