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The anti‐hepatic fibrosis effects of dihydrotanshinone I are mediated by disrupting the yes‐associated protein and transcriptional enhancer factor D2 complex and stimulating autophagy

BACKGROUND AND PURPOSE: Dihydrotanshinone I (DHI), a lipophilic component of traditional Chinese medicine Salvia miltiorrhiza Bunge, has various therapeutic effects. We investigated the anti‐fibrotic effect of DHI and its underlying mechanisms in vitro and in vivo. EXPERIMENTAL APPROACH: Rats subjec...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Ge, Maoxu, Liu, Hong, Zhang, Yixuan, Li, Naren, Zhao, Shuangshuang, Zhao, Wuli, Zhen, Yongzhan, Yu, Jianzhong, He, Hongwei, Shao, Rong‐guang
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406384/
https://ncbi.nlm.nih.gov/pubmed/28257144
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13766
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