Mucosal Expression of Type 2 and Type 17 Immune Response Genes Distinguishes Ulcerative Colitis From Colon-only Crohn’s Disease in Treatment-naïve Pediatric Patients

BACKGROUND & AIMS: There is controversy over the role of the type 2 immune response in pathogenesis of ulcerative colitis (UC)—few data are available from treatment-naïve patients. We investigated whether genes associated with a type 2 immune response in the intestinal mucosa are upregulated in...

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Published in:Gastroenterology
Main Authors: Rosen, Michael J., Karns, Rebekah, Vallance, Jefferson E., Bezold, Ramona, Waddell, Amanda, Collins, Margaret H., Haberman, Yael, Minar, Phillip, Baldassano, Robert N., Hyams, Jeffrey S., Baker, Susan S., Kellermayer, Richard, Noe, Joshua D., Griffiths, Anne M., Rosh, Joel R., Crandall, Wallace V., Heyman, Melvin B., Mack, David R., Kappelman, Michael D., Markowitz, James, Moulton, Dedrick E., Leleiko, Neal S., Walters, Thomas D., Kugathasan, Subra, Wilson, Keith T., Hogan, Simon P., Denson, Lee A.
Format: Artigo
Language:Inglês
Published: 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406257/
https://ncbi.nlm.nih.gov/pubmed/28132889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.01.016
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