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Initiation of aberrant DNA methylation patterns and heterogeneity in precancerous lesions of human hepatocellular cancer

While intratumor heterogeneity contributes to disease progression, metastasis, and resistance to chemotherapy, it also provides a route to understanding the evolution and drivers of disease. Defects in epigenetic landscapes are intimately linked to pathogenesis of a variety of human diseases, with e...

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Publicat a:Epigenetics
Autors principals: Hlady, Ryan A., Zhou, Dan, Puszyk, William, Roberts, Lewis R., Liu, Chen, Robertson, Keith D.
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5406211/
https://ncbi.nlm.nih.gov/pubmed/28059585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2016.1277297
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